EFAROXAN HYDROCHLORIDE
- Product Name
- EFAROXAN HYDROCHLORIDE
- CAS No.
- 89197-00-2
- Chemical Name
- EFAROXAN HYDROCHLORIDE
- Synonyms
- RX 821037A;EfaroxanHCl;Zinc00002748;PO20090827-Efaroxan;EFAROXAN HYDROCHLORIDE;(+/-)-efaroxan hydrochloride;Efaroxan hydrochloride >=98% (HPLC);2-ETHYL-2-(IMIDAZOLIN-2-YL)-2,3-DIHYDROBENZOFURAN HYDROCHLORIDE;2-(2-ETHYL-2,3-DIHYDROBENZOFURAN-2-YL)-4,5-DIHYDRO-1H-IMIDAZOLE HCL;2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
- CBNumber
- CB9376896
- Molecular Formula
- C13H17ClN2O
- Formula Weight
- 252.74
- MOL File
- 89197-00-2.mol
EFAROXAN HYDROCHLORIDE Property
- storage temp.
- Store at RT
- solubility
- H2O: 300 mg/mL
- form
- solid
- color
- White
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- E3263
- Product name
- Efaroxan hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- E3263
- Product name
- Efaroxan hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $348
- Updated
- 2024/03/01
- Product number
- 29008
- Product name
- Efaroxan (hydrochloride)
- Packaging
- 25mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 29008
- Product name
- Efaroxan (hydrochloride)
- Packaging
- 50mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 29008
- Product name
- Efaroxan (hydrochloride)
- Packaging
- 10mg
- Price
- $37
- Updated
- 2024/03/01
EFAROXAN HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Efaroxan HCl (89197-00-2) is a selective α2-adrenergic receptor antagonist1 (selectivity ratio of α2/α1 = 724)4 and imidazoline receptor antagonist2. Induces release of insulin in the rat insulinoma cell line RIN-5AH by interaction with ATP-sensitive potassium channels independently from imidazoline I1 or I2 receptors.3 Efaroxan HCl increases resting plasma insulin levels and markedly potentiates the rise in insulin levels produced by adrenaline in the rat.4
Uses
Efaroxan Hydrochloride is a potent α2-AR adrenoceptor antagonist.
Biological Activity
Potent, highly selective α 2 adrenoceptor antagonist and imidazoline I 1 receptor ligand (pK i values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A , α 2B , α 2C , I 1 , and I 2 receptors respectively). Promotes insulin secretion, at a site distinct from I 1 or I 2 (the putative I 3 receptor) in vitro and in vivo .
References
1) Chapleo et al. (1984), alpha-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on alpha-adrenoceptor activity; J.Med.Chem., 27 570 2) Eglen et al. (1998), ‘Seeing through a glass darkly’: casting light on imidazoline ‘I’ sites; Trends Pharmacol. Sci., 19 381 3) Olmos et al. (1994), Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors; Eur. .J. Pharmacol., 262 41 4) Berridge et al. (1992), Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats; Eur. J. Pharmacol., 213 205
EFAROXAN HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
EFAROXAN HYDROCHLORIDE Suppliers
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